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Lamotrigine Tablets, USP Starter Kits

NOW AVAILABLE Through ASPN Pharmacy

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Why Start with Lamotrigine Starter Kits?

Lamotrigine Starter Kits help simplify treatment initiation for you and your patients in a more structured way than is offered by multiple weekly prescriptions and a bottle of 25 mg tablets

Each Kit is based on FDA-approved 5-week titration schedules for patients initiating lamotrigine therapy

You only need to write one prescription for a 5-week Starter Kit

Each Kit comes with a week-by-week blister pack with perforated daily dosing for on-the-go use

With the Savings Card all patients can obtain the Lamotrigine Starter Kit at a significantly lower cost than Lamictal®*†1

How to Write

A

E-Prescribe

  • In your EHR system, type in “Lamotrigine Starter Kits”
  • Look for “Lamotrigine Starter Kits” Orange, Blue or Green Starter Kit (or dose pack)
  • Select the appropriate Kit by clicking on it
  • Select the DAW-1 box (may say brand medically necessary, etc.)
  • Save the selected Lamotrigine Starter Kit as a "favorite" for quick access in the future

B

Write DAW-1*

Write Lamotrigine Starter Kit (Orange, Blue, and Green) DAW-1

OWP Pharmaceuticals - Lamotrigine Starter Kits - Orange

Orange Starter Kit: Total 49 Tablets
(42 X 25mg) (7 X 100mg)
NDC 69102-137-10

OWP Pharmaceuticals - Lamotrigine Starter Kits - Blue

Blue Starter Kit: Total 35 Tablets
(35 X 25mg)
NDC 69102-639-09

OWP Pharmaceuticals - Lamotrigine Starter Kits - Green

Green Starter Kit: Total 98 Tablets
(84 X 25mg) (14 X 100mg)
NDC 69102-359-11

Pharmacists: Please use the NDC numbers listed above to place orders.

Where to Prescribe

In addition to Nationwide Retail Pharmacy Availability, OWP Patient Support administered by ASPN Pharmacies provides a dedicated service designed to help with access to Lamotrigine Starter Kits.

Dedicated and trained staff

Pharmacy Benefits investigation

Copay assistance

Prior authorization support

Free delivery

To Get Started with OWP Patient Support

1

In your EHR, save:

ASPN Pharmacies
ZIP: 07932
NCPDP#: 3147863
NPI: 1538590690

2

Send Lamotrigine Starter Kit Rx to ASPN Pharmacies

ePrescribe via EHR

3

Remind patients to confirm their Rx with ASPN Pharmacies

Ask them to respond to ASPN’s text or save 1-866-878-4625 as the contact “ASPN Pharmacies” in their phone

You are done! ASPN Pharmacy will contact your office directly if additional information is needed. They will work with your patient to get their prescription filled and delivered to them as soon as possible.

Resources

Download Savings Card
Download Titration Guides
Download How-to-Write Guide
Download ASPN Enrollment Form

LAMOTRIGINE STARTER KIT INFORMATION FOR THE PHARMACIST

Available through the wholesalers Amerisource, ANDA, Cardinal, McKesson, Smith, Morris & Dickson, Mutual, and others. If you have any questions, please contact OWP PHARMACEUTICALS at 1-800-273-6729

OWP PHARMACEUTICALS’ DRUGS

  • Lamotrigine Starter Kits
  • SUBVENITE® (lamotrigine) Starter Kits
  • ROWEEPRA® (levetiracetam)
Row Global Health Logo

A portion of the profits from each Lamotrigine Starter Kit prescription helps treat people with neurological disorders in under-resourced areas globally. Please visit www.rowglobal.org ↗ to learn more.

References

1. https://www.goodrx.com/lamictal?dosage=49-tablets-of-25mg-and-100mg-orange&form=kit&label_override=Lamictal&quantity=1
2. Center for Drug Evaluation and Research. Guidance for Industry: Statistical Approaches to Establishing Bioequivalence. Silver Spring, MD: Food and Drug Administration, US Department of Health and Human Services; 2001. http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/ucm070244.pdf. Accessed September 26, 2013.
3. Office of Generic Drugs, Center for Drug Evaluation and Research. Approved Drug Products With Therapeutic Equivalence Evaluations. 33rd ed. Silver Spring, MD: Food and Drug Administration, US Department of Health and Human Services; 2013. http://www.fda.gov/downloads/Drugs/DevelopmentApprovalProcess/ucm071436.pdf. Accessed September 26, 2013.

*Lamictal® is a registered trademark of GlaxoSmithKline, Inc.
†Terms and conditions apply; see lamotriginestarterkits.com/savings-program

For general questions or inquiries please contact us at: info@owppharma.com
For Lamotrigine Starter Kit questions please contact us at: medinfo@owppharma.com
To report safety-related concerns please contact us at: safety@owppharma.com

OWOS1083V6 3/25

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© 2024 OWP Pharmaceuticals, Inc. All rights reserved.
Naperville, IL 60563. Developed in USA.

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Important Safety Information

WARNING: SERIOUS SKIN RASHES

Cases of life-threatening serious rashes, including Stevens-Johnson syndrome and toxic epidermal necrolysis, and/or rash-related death have been caused by lamotrigine. The rate of serious rash is greater in pediatric patients than in adults. Additional factors that may increase the risk of rash include:

  • coadministration with valproate.
  • exceeding recommended initial dose of lamotrigine tablets.
  • exceeding recommended dose escalation of lamotrigine tablets.
  • presence of the HLA-B*1502 allele. (5.1)

Benign rashes are also caused by lamotrigine; however, it is not possible to predict which rashes will prove to be serious or life threatening. Lamotrigine tablets should be discontinued at the first sign of rash, unless the rash is clearly not drug related. (5.1)

See full prescribing information for complete boxed warning, including Medication Guide at www.lamotriginestarterkits.com.
 

Lamotrigine tablet is indicated for:
Epilepsy-adjunctive therapy in patients aged 2 years and older:

  • partial-onset seizures.
  • primary generalized tonic-clonic (PGTC) seizures.
  • generalized seizures of Lennox-Gastaut syndrome. (1.1)
 

Epilepsy-monotherapy in patients aged 16 years and older: Conversion to monotherapy in patients with partial-onset seizures who are receiving treatment with carbamazepine, phenytoin, phenobarbital, primidone, or valproate as the single antiepileptic drug. (1.1)

Bipolar disorder: Maintenance treatment of bipolar I disorder to delay the time to occurrence of mood episodes in patients treated for acute mood episodes with standard therapy. (1.2)

Limitations of Use: Treatment of acute manic or mixed episodes is not recommended. Effectiveness of lamotrigine tablets in the acute treatment of mood episodes has not been established.

DOSAGE AND ADMINISTRATION

  • Dosing is based on concomitant medications, indication, and patient age. (2.1, 2.2, 2.3, 2.4)
  • To avoid an increased risk of rash, the recommended initial dose and subsequent dose escalations should not be exceeded. Lamotrigine Tablets Starter Kits are available for the first 5 weeks of treatment. (2.1, 16)
  • Do not restart lamotrigine tablets in patients who discontinued due to rash unless the potential benefits clearly outweigh the risks. (2.1, 5.1)
  • Adjustments to maintenance doses will be necessary in most patients starting or stopping estrogen-containing products, including oral contraceptives. (2.1, 5.9)
  • Discontinuation: Taper over a period of at least 2 weeks (approximately 50% dose reduction per week). (2.1, 5.10)
 

Epilepsy:
Adjunctive therapy-See Table 1 for patients older than 12 years and Tables 2 and 3 for patients aged 2 to 12 years. (2.2)
Conversion to monotherapy—See Table 4. (2.3)
Bipolar disorder: See Tables 5 and 6. (2.4)

DOSAGE FORMS AND STRENGTHS

  • Tablets: 25 mg, 100 mg; scored. (3.1, 16)
 

CONTRAINDICATIONS

Hypersensitivity to the drug or its ingredients. (Boxed Warning, 4)

WARNINGS & PRECAUTIONS

  • Life-threatening serious rash and/or rash-related death: Discontinue at the first sign of rash, unless the rash is clearly not drug related. (Boxed Warning, 5.1).
  • Hemophagocytic lymphohistiocytosis: Consider this diagnosis and evaluate patients immediately if they develop signs or symptoms of systemic inflammation. Discontinue lamotrigine tablets if an alternative etiology is not established. (5.2)
  • Fatal or life-threatening hypersensitivity reaction: Multiorgan hypersensitivity reactions, also known as drug reaction with eosinophilia and systemic symptoms, may be fatal or life threatening. Early signs may include rash, fever, and lymphadenopathy. These reactions may be associated with other organ involvement, such as hepatitis, hepatic failure, blood dyscrasias, or acute multiorgan failure. Lamotrigine tablets should be discontinued if alternate etiology for this reaction is not found.(5.3)
  • Cardiac rhythm and conduction abnormalities: Based on in vitro findings, lamotrigine tablets could cause serious arrhythmias and/or death in patients with certain underlying cardiac disorders or arrhythmias. Any expected or observed benefit of lamotrigine tablets in an individual patient with clinically important structural or functional heart disease must be carefully weighed against the risk for serious arrythmias and/or death for that patient. (5.4)
  • Blood dyscrasias (e.g., neutropenia, thrombocytopenia, pancytopenia): May occur, either with or without an associated hypersensitivity syndrome. Monitor for signs of anemia, unexpected infection, or bleeding. (5.5)
  • Suicidal behavior and ideation: Monitor for suicidal thoughts or behaviors. (5.6)
  • Aseptic meningitis: Monitor for signs of meningitis. (5.7)
  • Medication errors due to product name confusion: Strongly advise patients to visually inspect tablets to verify the received drug is correct. (5.8, 16, 17)
 

ADVERSE REACTIONS

Epilepsy: Most common adverse reactions (incidence ≥10%) in adults were dizziness, headache, diplopia, ataxia, nausea, blurred vision, somnolence, rhinitis, pharyngitis, and rash. Additional adverse reactions (incidence ≥10%) reported in children included vomiting, infection, fever, accidental injury, diarrhea, abdominal pain, and tremor. (6.1)

Bipolar Disorder: Most common adverse reactions (incidence >5%) in adults were nausea, insomnia, somnolence, back pain, fatigue, rash, rhinitis, abdominal pain, and xerostomia. (6.1)

To report SUSPECTED ADVERSE REACTIONS, contact OWP Pharmaceuticals Inc. at 1-800-273-6729 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

DRUG INTERACTIONS

  • Valproate increases lamotrigine concentrations more than 2-fold. (7, 12.3)
  • Carbamazepine, phenytoin, phenobarbital, primidone, and rifampin decrease lamotrigine concentrations by approximately 40%. (7, 12.3)
  • Estrogen-containing oral contraceptives decrease lamotrigine concentrations by approximately 50%. (7, 12.3)
  • Protease inhibitors lopinavir/ritonavir and atazanavir/lopinavir decrease lamotrigine exposure by approximately 50% and 32%, respectively. (7, 12.3)
  • Coadministration with organic cationic transporter 2 substrates with narrow therapeutic index is not recommended (7, 12.3)
 

USE IN SPECIFIC POPULATIONS

  • Pregnancy: Based on animal data may cause fetal harm. (8.1)
  • Hepatic impairment: Dosage adjustments required in patients with moderate and severe liver impairment. (2.1, 8.6)
  • Renal impairment: Reduced maintenance doses may be effective for patients with significant renal impairment. (2.1, 8.7)
 

See 17 for PATIENT COUNSELING INFORMATION and Medication Guide.

Please refer to the full Prescribing Information at www.lamotriginestarterkits.com.

Revised: 11/2025

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